Table 4. The main analysis results of SROC.

Sample	Sensitivity (95% CI)	Specificity (95% CI)	a (95% CI)	b (95% CI)	AUC	Q* (95% CI)
Saliva	0.47 (0.39 - 0.55)	0.89 (0.85 - 0.91)	2.14 (1.71-2.56)	−0.02 (-0.14-0.09)	0.80	0.74 (0.70-0.78)
Tissue	0.57(0.5 - 0.63)	0.88(0.84 - 0.90)	2.91 (2.37 - 3.44)	0.07 (−0.11 - 0.25)	0.82	0.81 (0.77-0.85)
Blood	0.46 (0.32 - 0.61)	0.85 (0.77 -.91)	1.75 (0.,74 - 2.77)	−0.09 (−0.42 - 0.24)	0.77	0.71 (0.59 - 0.80)

Sensitivity and Specificity represent the independent pooled sensitivity (Se) and specificity (Sp) using fixed effect model. a and b represent the intercept and slope of SROC curve. AUC represent the area under SROC curve. Q* represents the diagnostic threshold at which the probability of a correct diagnosis is constant for all subjects and calculated as exp(a/2)/[1+exp(a/2)].