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Observation assessment LSMs profile with 95% confidence interval as error bars (first 3 h after administration). Grey closed circle represents midazolam 2.5 mg intravenous (IV); black closed circle represents midazolam 2.5 mg intranasal (IN); open circle represents midazolam 5.0 mg IN. Score 1 = awake/oriented; score 2 = drowsy/normal speech; score 3 = slow reaction to verbal; score 4 = inability 2 saccades
