Table 3.

Central nervous system (CNS) toxic effects described by health professionals to the UK National Poisons Information Service after reported overdose of mefenamic acid, ibuprofen, diclofenac and naproxen. Patients with reported co‐exposures have been excluded. Note that some patients may experience more than one feature

	Diclofenac (n = 1300)	Ibuprofen (n = 8090)	Mefenamic acid (n = 461)	Naproxen (n = 547)
CNS toxicity	35 (2.7%)	163 (2.0%)	91 (19.7%)	33 (6.0%)
Confusion	1 (0.1%)	12 (0.1%)	4 (0.9%)	2 (0.4%)
Anxiety	1 (0.1%)	4 (0.05%0	3 (0.7%)	1 (0.2%)
Convulsions	1 (0.1%)	5 (0.06%)	42 (9.1%)	0 (0.0%)
Reduced conscious level	18 (1.4%)	92 (1.1%)	30 (6.5%)	23 (4.2%)
Dizziness	15 (1.2%)	47 (0.6%)	12 (2.6%)	5 (0.9%)
Agitation/Aggression	2 (0.2%)	7 (0.09%)	16 (3.5%)	3 (0.5%)