Table 4.

Adjusted and unadjusted odds ratios (ORs) for the association between central nervous system (CNS) toxicity and drug exposure. Note: to analyse the association between drug exposure and convulsion, a different model was used, in which mefenamic acid was compared with all other nonsteroidal anti‐inflammatory drugs (NSAIDs) as the number of patients who developed convulsions was small and not all NSAIDs were associated with convulsion

	Unadjusted analysis (n = 10 398)				Adjusted analysis (n = 7711)
	OR	Lower 95% CI	Upper 95% CI	P‐value	OR	Lower 95% CI	Upper 95% CI	P‐value
CNS toxicity outcome
Mefenamic acid vs. ibuprofen	11.96	9.07	15.78	<0.001	11.86	8.75	16.07	<0.001
Mefenamic acid vs. diclofenac	8.89	5.92	13.35	<0.001	9.02	5.73	14.20	<0.001
Mefenamic acid vs. naproxen	3.83	2.52	4.54	<0.001	3.80	2.40	4.49	<0.001
Naproxen vs. ibuprofen	3.12	2.13	4.59	<0.001	3.12	2.03	4.79	<0.001
Naproxen vs. diclofenac	2.32	1.43	3.77	0.007	2.37	1.37	4.09	0.002
Diclofenac vs. ibuprofen	1.35	0.93	1.95	0.116	1.32	0.86	2.01	0.204
Mefenamic acid vs. all others	9.79	7.52	12.74	<0.001	7.77	5.68	10.62	<0.001
Convulsions outcome
Mefenamic acid vs. all others	900.0	34.7	233.2	<0.001	81.5	27.8	238.8	<0.001

CI, confidence interval