Table 1.
Patient baseline characteristics and demographics, and laboratory results obtained on day 6 post‐transplantation
| Age group | |||
|---|---|---|---|
| Young (19.2–58.4 years) n = 54 | Elderly (60.1–76.2 years) n = 26 | P‐ value | |
| Age (years) | 43.7 ± 11.0 | 65.8 ± 4.9 | <0.001b |
| Weight (kg) | 78.9 ± 19.0 | 83.5 ± 14.6 | 0.21b |
| Male sex, n (%) | 38 (70.4) | 23 (88.5) | 0.15c |
| Ethnicity, n (%) | |||
| Caucasian | 45 (83.3) | 23 (88.5) | 0.75c |
| Black | 7 (13.0) | 3 (11.5) | |
| Asian | 2 (3.7) | 0 (0) | |
| ATG induction therapy, n (%) | 16 (29.6) | 7 (26.9) | 0.87c |
| DGF, n (%) | 17 (31.4) | 6 (23.1%) | 0.47b |
| MMF daily dose (mg day −1 ) | 1984 ± 170 | 1918 ± 188 | 0.16b |
| Tacrolimus daily dose (mg) | 11.1 ± 3.6 | 11.0 ± 3.3 | 0.88b |
| Tac trough (μg l −1 ) | 10.4 ± 5.5 | 18.5 ± 8.3 | <0.001b |
| Tac trough, dose and weight normalized (ng ml −1 mg −1 ) | 76.8 ± 56.0 | 150.2 ± 93.1 | 0.004 |
| Albumin (g l −1 ) | 34.2 ± 5.9 | 33.8 ± 3.7 | 0.59b |
| Creatinine clearance a (ml min −1 per 1. 73 m 2 ) | 29.3 ± 21.8 | 38.3 ± 24.1 | 0.10b |
| Leucocytes (10 9 l −1 ) | 9.1 ± 4.9 | 8.9 ± 4.5 | 0.91b |
ATG, anti‐thymocyte globulin; DGF, delayed graft function
a
Estimated using MDRD equation
b
t‐test
c
Pearson's χ2 test; data are expressed as mean ± SD