Table 4.
Comparison of PK and PD parameters in elderly and younger patients
| Age group (years) | ||||||
|---|---|---|---|---|---|---|
| 19.2–37 (n = 15) | 37.3–46.7 (n = 15) | 47.3–56.5 (n = 20) | 56.6–64.1 (n = 15) | 64.3–76.2 (n = 15) | P value a | |
| Age (years) | 29.1 ± 6.4 | 42.3 ± 2.7 | 52.9 ± 2.7 | 60.4 ± 2.4 | 68.9 ± 4.1 | 0.00 |
| IMPDH baseline (μmol s −1 mol −1 AMP) | 46.1 (33.6–77.1) | 38.8 (19.9–72.7) | 55.9 (26.3–74.3) | 42.7 (27.3–49.1) | 44.4 (23.3–76.7) | 0.63 |
| AEC 0–12h (h.μmol s −1 mol −1 AMP) | 213 (152–346) | 238 (199–280) | 255 (184–379) | 178 (111–234) | 289 (186–344) | 0.68 |
| AUC 0–12h (h.mg l −1 ) | 39.0 (23–49.6) | 40.2 (26.1–49.8) | 25.6 (15–37.6) | 33.9 (25.7–48.2) | 32.5 (30.3–38.6) | 0.59 |
| Maximum IMPDH inhibition (%) | 43.7 (38.3–48.2) | 57.2 (46.1–68.6) | 43.3 (33.0–70.9) | 42.7 (31.2–59.6) | 47.1 (43.4–71.8) | 0.56 |
| E max (μmol s −1 mol −1 AMP) | 54.5 (38.8–77.0) | 36.9 (26.9–69.2) | 47.8 (23.5–75.5) | 47.9 (35.1–65.0) | 56.5 (40.1–80.9) | 0.74 |
| EC 50 (mg l −1 ) | 1.76 (0.73–6.32) | 3.94 (0.79–8.40) | 4.72 (0.93–8.20) | 1.87 (1.21–6.20) | 1.36 (0.91–3.81) | 0.84 |
AEC0–12h, the area under the effect–time curve for the IMPDH activity; AUC0–12h, the area under the concentration–time curve of mycophenolic acid; EC50, the MPA concentration at half E max; E max, the maximal inhibitory effect; IMPDH, inosine monophosphate dehydrogenase
a
non‐parametrical anova (Kruskal–Wallis test, followed by Schaich–Hammerle post hoc analysis)