Table 1.
No. of DLBCL patients | ||
---|---|---|
Characteristics | total (n = 75) | planned to receive ASCT (n = 24) |
Sex (male/female) | 42/33 | 12/12 |
Age (years; median, IQR) | 61 (47-71) | 50 (41-57) |
Ann Arbor III & IV | 61 | 21 |
High LDH | 57 | 21 |
ECOG≥2 | 26 | 11 |
>1 extranodal presentation | 37 | 12 |
Bulky disease | 28 | 11 |
Ki-67 ≥ 80% | 31 | 8 |
Ki-67 ≥ 90% | 18 | 7 |
B symptoms | 37 | 15 |
IPI≥2 | 64 | 20 |
Age-adjusted IPI≥2 | - | 18 |
R-IPI poor risk | 45 | 12 |
R-DA-EPOCH cycles (median, IQR) | 6 (6-8) | 7 (6-7) |
ASCT transplantation | 17 | 17 |
CD34+ cells mobilized with EPOCH | - | 18/21† |
Irradiation | 7 | 2 |
*Abbreviations: IQR – interquartile range; LDH – lactate dehydrogenase; ECOG – Eastern Cooperative Oncology Group; B symptoms – fever, weight loss, and night sweats; IPI –International Prognostic Index; R-IPI – revised IPI; R-DA-EPOCH – rituximab plus dose-adjusted regimen combining etoposide, prednisone, vincristine, cyclophosphamide, and doxorubicin.
†Three patients planned to receive ASCT died prior to stem cell mobilization.