Table 3.
Signal Transduction Pathway Associations
| Pathway | Pathway ID | p-Value |
|---|---|---|
| Upregulated | ||
| TGF-β | PW_TGFBR_MUS_MUSCULUS | 1.69E-18 |
| Mothers against DPP homolog | PW_SMAD_MUS_MUSCULUS | 1.06E-08 |
| Matrix metalloproteinase | PW_MMP_MUS_MUSCULUS | 7.90E-05 |
| Platelet/endothelial cell adhesion molecule 1 (CD31) | PW_PECAM1_MUS_MUSCULUS | 1.08E-04 |
| Vascular endothelial growth factor | PW_VEGF_MUS_MUSCULUS | 1.90E-04 |
| CCAAT/enhancer binding protein (C/EBP), Alpha | PW_CEBPA_MUS_MUSCULUS | 1.94E-04 |
| Platelet-derived growth factor | PW_PDGF_MUS_MUSCULUS | 3.20E-04 |
| Chemokine (C C Motif) ligand 2 | PW_CCL2_MUS_MUSCULUS | 4.71E-04 |
| Wingless type | PW_WNT_MUS_MUSCULUS | 5.05E-04 |
| Fibroblast growth factor | PW_FGF_MUS_MUSCULUS | 5.26E-04 |
| Indian hedgehog | PW_SHH_MUS_MUSCULUS | 6.22E-04 |
| Nuclear receptor subfamily 2, group F, member 2 | PW_NR2F2_MUS_MUSCULUS | 7.42E-04 |
| Low-density lipoprotein receptor related protein | PW_LRP_MUS_MUSCULUS | 8.34E-04 |
| C kit | PW_C KIT_MUS_MUSCULUS | 1.26E-03 |
| Cadherin 1, type 1, E cadherin (Epithelial) | PW_CDH1_MUS_MUSCULUS | 2.15E-03 |
| Angiotensin | PW_AGT_MUS_MUSCULUS | 2.57E-03 |
| Hedgehog | PW_HH_MUS_MUSCULUS | 2.70E-03 |
| Patched homolog 1 (drosophila) | PW_PTCH1_MUS_MUSCULUS | 5.87E-03 |
| Beta catenin | PW_BETA CATENIN_MUS_MUSCULUS | 6.45E-03 |
| Rho associated, coiled coil containing protein kinase | PW_ROCK_MUS_MUSCULUS | 6.65E-03 |
| FMS-like receptor tyrosine kinase 3 | PW_FLT3_MUS_MUSCULUS | 7.73E-03 |
| Peroxisome proliferator activated receptor delta | PW_PPARD_MUS_MUSCULUS | 8.07E-03 |
| Notch | PW_NOTCH_MUS_MUSCULUS | 8.98E-03 |
| NF kappa B | PW_NFKB_MUS_MUSCULUS | 9.51E-03 |
| Caveolin 1 | PW_CAVEOLIN_MUS_MUSCULUS | 9.80E-03 |
| Downregulated | ||
| Integrin | PW_INTEGRIN_MUS_MUSCULUS | 1.87E-07 |
| Spleen tyrosine kinase | PW_SYK_MUS_MUSCULUS | 2.58E-05 |
| V yes1 Yamaguchi sarcoma viral related oncogene Homolog; Lck/yes-related novel protein tyrosine kinase | PW_LYN_MUS_MUSCULUS | 2.84E-04 |
| Myeloid differentiation primary response gene (88) | PW_MYD88_MUS_MUSCULUS | 4.42E-04 |
| Bruton's tyrosine kinase | PW_BTK_MUS_MUSCULUS | 5.06E-04 |
| Zeta chain (TCR) associated protein kinase 70 kDa | PW_ZAP_70_MUS_MUSCULUS | 8.22E-04 |
| Cadherin 1, type 1, E cadherin (epithelial) | PW_CDH1_MUS_MUSCULUS | 8.34E-04 |
| Interleukin 6 signal transducer (GP130, oncostatin M receptor) | PW_IL6ST_MUS_MUSCULUS | 3.04E-03 |
| Protein kinase C | PW_PKC_MUS_MUSCULUS | 3.13E-03 |
| Epidermal growth factor | PW_EGF_MUS_MUSCULUS | 3.28E-03 |
| CD19 | PW_CD19_MUS_MUSCULUS | 3.96E-03 |
| Tyrosine protein kinase SRC | PW_SRC_MUS_MUSCULUS | 5.53E-03 |
| Hepatocyte growth factor receptor | PW_HGF_MUS_MUSCULUS | 5.96E-03 |
| Signal transducer and activator of transcription | PW_STAT_MUS_MUSCULUS | 6.44E-03 |
| Gardner Rasheed feline sarcoma viral (V FGR) Oncogene homolog | PW_FGR_MUS_MUSCULUS | 7.97E-03 |
| C terminal SRC kinase | PW_CSK_MUS_MUSCULUS | 8.38E-03 |