Table 1.
Previously reported cases of malignant acanthosis nigricans (MAN) associated with gynaecological malignancies
| First author [ref.], year | Patient age, years/gender | Presentation | MAN distribution | Malignancy |
|---|---|---|---|---|
| Dingley [14], 1957 | 56/F | Warts presenting on arms, legs, and trunk; dry/sore tongue and cheeks; no B symptoms | Arms, legs, trunk, face, oral, palms, soles, anus, groin, axillae | Ovarian adenocarcinoma |
| Curth [3], 1962 | 55/F | Vaginal discharge, postmenopausal bleeding | Dorsa of hands, forearms, back, trunk, legs, umbilicus, axillae, perianal and vulvar | Endometrial carcinoma |
| Mikhail [4], 1979 | 58/F | Condylomata of the perineum | Face, oral involvement, palms and soles, perineal region, inframammary region, vulva, anus, gluteal cleft, upper thigh, axillae | Cervical squamous cell carcinoma |
| Requena [5], 1995 | 83/F | 8 months of increasing hyperkeratosis of palms, 5 months of anorexia and weight loss, and 3 months of night sweats | Palms, dorsum of hands, axillae and groin | Ovarian carcinoma |
| Gorisek [6], 1997 | 54/F | Postmenopausal menorrhagia | Tripe palms, dorsal neck, axilla, inframammary region, abdominal folds, inguinal and forearms; oral involvement also | Endometrial adenocarcinoma |
| Mekhail [1], 2002 | 69/F | Hypothyroidism, obesity | Tripe palms, face, neck, axillae, groin and inframammary region | Endometrial adenocarcinoma |
| Tsai [7], 2004 | 55/F | Cervical cancer | Palms, dorsum of hand, soles, thighs, neck, axillar, waist | Cervical cancer |
| Longshore [8], 2003 | 69/F | Anorexia, weight loss | Face, axillae, groin, hands, soles, inframammary folds | Endometrial adenocarcinoma |
| Kebria [9], 2006 | 52/F | Weight loss | Neck, axillae, inframammary, palms and soles, groin and oral involvement, tripe palms | Ovarian adenocarcinoma |
| Oh [10], 2010 | 57/F | No B symptoms | Neck, axillae, groin, oral, forearms, palms and soles | Ovarian adenocarcinoma |
| Singh [11], 2013 | 47/F | Fatigue, weight loss, and night sweats for 8 months | Face and body | Ovarian adenocarcinoma |
| Chu [12], 2014 | 59/F | Previous endometrial carcinoma (9 years before) | Face, elbows, pudendum, groin, axillae, nipples | Endometrial carcinoma |
| Garzitto [13], 2015 | 60/F | Vitiligo and AN; otherwise well, no B symptoms | Axillary, inframammary region, inguinal, genital, perioral, tripe palms | Ovarian adenocarcinoma |