Table 3.
Baseline characteristics and cognitive change over 2 years from baseline of the patients who remained stable or improved within the GDS range 2–3 (SCI/MCI) and of those who declined to GDS 3 or 4 (MCI/dementia) after 6 years
| Declined to GDS 3 or 4 (n = 11) | Stable within GDS 2–3 (n = 70) | p value | |
|---|---|---|---|
| Baseline characteristics | |||
| Age, years | 61.0 (5.7) | 61.0 (7.8) | 0.96 |
| Education, years | 11.7 (3.3) | 12.4 (3.1) | 0.55 |
| MMSE | 28.5 (0.9) | 28.7 (1.2) | 0.51 |
| P-tau, ng/L | 62.9 (21.7) | 55.4 (18.2) | 0.35 |
| T-tau, ng/L | 264.8 (87.4) | 295.2 (152.8) | 0.52 |
| Aβ42, ng/L | 625.6 (227.3) | 716.8 (249.1) | 0.26 |
| T-tau/Aβ42 ratio | 0.48 (0.3) | 0.49 (0.4) | 0.93 |
| Average Memory T score | 52.3 (6.6) | 54.9 (7.6) | 0.28 |
| Average Executive T score | 52.2 (9.2) | 53.2 (5.6) | 0.61 |
| Cognitive change over 2 years from baseline | |||
| Average Memory T-score change | -4.6 (10.0) | +1.6 (7.7) | 0.02* |
| Average Executive T-score change | -0.8 (4.6) | +1.3 (5.6) | 0.23 |
Values in parentheses are SD.
*
p ≥ 0.05.