Figure 5.
Major chemical degradation pathways of compound 1. (A) Solvolysis under alkaline pH in buffered aqueous solution rapidly leads to multiple fragmentation byproducts.27 (B) Autoxidation in buffered medium creates a bicyclopentadione (8) that is the major degradation product in aqueous conditions.66 (C) Photodegradation of 1 can occur when in crystalline form and dissolved in organic solvent.68 (D) When dissolved in certain organic solvents (like isopropanol), photodegradation can include reaction with the solvent as a substrate.69