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. 2017 Jan 23;8(3):321–326. doi: 10.1021/acsmedchemlett.6b00491

Table 1. B-Ring SARs on Oxygen Affinity with Fused Bicyclics.

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a

Data expressed as Δp50%: the % change from baseline of pO2 at which HbS (at 25 μM) is 50% saturated with O2 in the presence of test compound at 30 μM. Please see Supporting Information for standard deviation and number of tests.