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X-ray cocrystal structure of Dot1L with 7 (pdb code 5mw4). Surface representation of Dot1L (gray) and stick model of ligand 7 (blue). Amino acid side chains engaging in key interactions with the ligand illustrated as sticks and polar contacts highlighted as dotted red lines. Inset: Overlay of the purine region of 7 (blue) and 2 (gray, crystal water in red) from the ternary structure.
