Table 2. Single-Dose Pharmacokinetic Parameters of 1c(42).

	mouse		rat		dog		monkey
	iv	po	iv	po	iv	po	iv	po
dose (mg/kg)	1	10	1	10	1	5	1	5
Vss (L/kg)	7.0		2.9		5.5		5.7
CLTp (mL/min/kg)	96		70		15		17
Cmax (μM)		0.55		1.6		3.2		1.3
t1/2 (h)	1.1		0.7		5.5		4.4
AUC (μM·h)	0.53	3.2	0.75	7.2	3.4	19	3.0	11
%F		45		97		100		70