. 2017 Feb 14;8(3):299–303. doi: 10.1021/acsmedchemlett.6b00465

Table 4. Monkey PK^a Profile of (+)/(−)-Lesinurad after a Single Dosing of (±)-Lesinurad.

parameters		(−)-lesinurad	(+)-lesinurad	(−)/(+)-index
IV	dose^b	2 mg/kg of (±)-lesinurad
	AUC_0-inf (μM·h)	14.5 ± 3.3	10.0 ± 2.8	1.4
	CL_p (mL/min/kg)	5.9 ± 1.5	8.8 ± 2.7	0.7
	C_{0–24h,urine} (μM)	5.4 ± 0.9	2.8 ± 1.4	1.9
PO	dose^c	10 mg/kg of (±)-lesinurad
	AUC_0-inf (μM·h)	99.4 ± 29.7	28.2 ± 19.2	3.5
	C_{0–24h,urine} (μM)	153.3 ± 93.5	38.0 ± 20.7	4.0

Monkey PK data is mean ± SD, n = 3.

IV formulation: 2.00 mg/mL in DMSO/PEG400/H₂O(5/40/55), clear solution.

PO formulation: 2 mg/mL in DMSO/0.5%MC(5/95), suspension.

Table 4. Monkey PKa Profile of (+)/(−)-Lesinurad after a Single Dosing of (±)-Lesinurad.