Table 3. Demographic-clinical characteristics of the SMD subtypes.
| HC-like SMD (n = 75) | AD-like SMD (n = 11) | Uncorrected p-value | BH corrected p-value | |
|---|---|---|---|---|
| Age | 72.5 (6.8) | 75.3 (8.8) | 0.292 | 0.985 |
| Gender, % female | 56 | 27 | 0.076 | 0.528 |
| Education level | 2 (1–4) | 3 (1–4) | 0.973 | 0.985 |
| MMSE | 28.7 (1.2) | 27.8 (1.7) | 0.088 | 0.528 |
| CDR-SOB | 0.0 (0.1) | 0.2 (0.3) | 0.001 | 0.008 |
| HADS-D | 2.9 (2.2) | 3.3 (3.1) | 0.985 | 0.985 |
| HADS-A | 4.8 (3.0) | 5.4 (3.3) | 0.658 | 0.985 |
| APOE, % ε4 carriers | 36 | 55 | 0.243 | 0.985 |
| 0 ε4 alleles, n | 48 | 5 | — | — |
| 1 ε4 allele, n | 26 | 5 | — | — |
| 2 ε4 alleles, n | 1 | 1 | — | — |
Values in the table represent the mean and standard deviation except for gender and APOE where the percentage is shown; for education level, where median and minimum–maximum is shown (Education level: 0 = 0–6 years, 1 = 7–8 years, 2 = 9–12 years, 3 = 13–15 years, 4 = 15+); and for the number of APOE ε4 alleles, where count is shown. The same results were obtained for MMSE and CDR-SOB when controlling for age, gender, education level and HADS-D. SMD = subjective memory decline; HC-like SMD = SMD individuals evidencing a healthy-like pattern of brain atrophy; AD-like SMD = SMD individuals evidencing an Alzheimer’s disease-like pattern of brain atrophy; BH = Benjamini-Hochberg; MMSE = Mini-Mental State Examination; CDR-SOB = Clinical Dementia Rating–Sum of Boxes; HADS = Hospital Anxiety and Depression Scale (D = depression subscale score; A = anxiety subscale score); APOE = apolipoprotein E e4 allele.