Table 1.

Key Table

Summary of the Relative Importance of the Different Drug Properties for the Different Use Scenarios^a

	Property					Refs
	Clearance of Blood-Stage Parasites	Duration of Prophylaxis	Enhanced Gametocytocidal Activityb	Mosquitocidal Activity	Hypnozoite Activityc
First-line treatment	+++	++	+	+	++	23, 25, 42, 45, 46, 49, 50, 61
Chemoprevention: children	+++	+++	??	??	??	44, 52, 89, 90
Chemoprevention: pregnant women	+++	+++	??	??	??	56, 57
MDA: elimination	++	++	+	+++	+++	36, 37, 38, 39, 42, 60
MDA: emergencies	++	++	+	??	??	62, 63

^aThe rankings are based on a review of the modelling literature with the key references shown in the final column. +++ = very important; ++ = moderately important; + = limited importance; ?? = further research required.

^bEnhanced gametocytocidal activity refers to that greater than current ACTs.

^cRelevant to Plasmodium vivax only.