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. 2017 Mar 13;7:44206. doi: 10.1038/srep44206

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Copyright © 2017, The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Optimal drug scheduling strategies solved by Algorithm 1 (SI, Section 2.2) for representative initial tumor cell distributions (A),(C), for a 30 day timeframe and 30, 15, 10, 5, 3 and 1 day minimum switching horizons, give one EGFR TKI, either 1.5 μM erlotinib (ERL) or 0.5 μM afatinib (AFA) in combination with either 5 μM vemurafenib (VEM), 0.5 μM trametinib (TRA) or 0.5 μM crizotinib (CRI) and corresponding simulations (B,D) of the lung adenocarcinoma evolutionary dynamics for a subset of optimal drug scheduling strategies.