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. 2017 Mar 13;7:44330. doi: 10.1038/srep44330

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Hyperuricemia-causing uric acid can be degraded into 5-hydroxyisourate (5HIU) and hydrogen peroxide (H₂O₂) by urate oxidase (UOX) enzyme in the presence of oxygen and water (left side). A potentially toxic hydrogen peroxide can be dissociated into oxygen and water by AuNP nanozyme (right side). In the presence of both UOX enzyme and AuNP nanozyme, uric acid degradation increases.