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. 2017 Mar 10;8(2):323–336. doi: 10.3945/an.116.013938

TABLE 1.

Baseline study characteristics of single-micronutrient interventions in children ≥2 y of age1

Study Year Country Subjects, n Mean initial age, mo Dose Duration, mo Mean initial HAZ Quality
Iron
 Aguayo (10) 2000 Bolivia 64 111 3 mg/kg bw 4 −1.48 High
 Angeles et al. (11) 1993 Indonesia 76 37 30 mg 2 −2.26 Medium
 Bhatia and Seshadri 1 (12) 1992 India 105 47 40 mg 6 −2.3 Medium
 Bhatia and Seshadri 2 (12) 1992 India 51 54 40 mg 6 −1.56 Medium
 Chen et al. (13) 2008 China 132 48 8.57 mg 6 −0.23 Medium
 Chwang et al. (14) 1988 Indonesia 41 128 10 mg/kg bw 3 −1.52 Medium
 Dossa et al. (15) 2001 Benin 68 47 60 mg 3 −2.26 Medium
 Hettiarachchi et al. (16) 2008 Sri Lanka 374 167 35.71 mg 6 −1.19 Medium
 Latham et al. (17) 1990 Kenya 55 96 285.7 mg 1 −0.88 High
 Lawless et al. (18) 1994 Kenya 86 105 150 mg 3 −1.23 High
 Mwanri et al. 1 (19) 2000 Tanzania 68 132 85.7 mg 3 −2.2 High
 Mwanri et al. 2 (19) 2000 Tanzania 68 126 85.7 mg 3 −1.56 High
 Palupi et al. (20) 1997 Indonesia 187 42 4.29 mg 2 −1.82 Medium
 Pereira et al. (21) 1979 India 44 42 10 mg 5 — Low
 Rahman et al. (22) 1999 Bangladesh 147 34 15 mg 12 −2.2 High
 Sungthong et al. 1 (23) 2002 Thailand 200 116 300 mg 4 −1.55 High
 Sungthong et al. 2 (23) 2002 Thailand 190 116 42.86 mg 4 −1.49 High
Zinc
 Castillo-Durán et al. 1 (24) 1994 Chile 19 169 10 mg 12 −2.58 High
 Castillo-Durán et al. 2 (24) 1994 Chile 18 138 10 mg 12 −2.61 High
 Cavan et al. (25) 1993 Guatemala 156 82 7.14 mg 6 −1.38 High
 Friis et al. (26) 1997 Zimbabwe 276 134 40 mg 12 −1.18 High
 Gibson et al. (27) 1989 Canada 60 75 10 mg 12 −1.39 High
 Hettiarachchi et al. (16) 2008 Sri Lanka 382 161 10 mg 6 −1.1 High
 Kaseb and Fallah (28) 2013 Iran 95 146 5 mg 4 −0.6 High
 Kikafunda et al. (29) 1998 Uganda 113 56 10 mg 6 −0.7 High
 Mozaffari-Khosravi et al. 1 (30) 2009 Iran 47 39 5 mg 6 −1.58 Medium
 Mozaffari-Khosravi et al. 2 (30) 2009 Iran 38 40 5 mg 6 −1.65 Medium
 Nakamura et al. (31) 1993 Japan 21 70 5 mg 6 −2.44 Low
 Ronaghy et al. (32) 1969 Iran 27 156 28 mg 5 −2.73 Low
 Ronaghy et al. (33) 1974 Iran 39 156 40 mg 12 −3.02 Low
 Rosado et al. (34) 1997 Mexico 95 29 20 mg 12 −1.7 High
 Ruz et al. (35) 1997 Chile 53 40 10 mg 14 −0.52 High
 Sayeg Porto et al. (36) 2000 Brazil 18 116 5 mg/kg bw 6 −2.67 Medium
 Sempértegui et al. (37) 1996 Ecuador 48 42 10 mg 2 −2 High
 Taneja et al. (38) 2010 India 421 27 20 mg 4 — High
 Walravens et al. (39) 1983 United States 40 50 10 mg 12 −2.07 High
Calcium
 Bass et al. 1 (40) 2007 Australia 47 109 800 mg 9 0.47 High
 Bass et al. 2 (40) 2007 Australia 41 109 800 mg 9 0.36 High
 Bonjour et al. (41) 1997 Switzerland 108 95 850 mg 12 0.3 High
 Cameron et al. (42) 2004 Australia 48 124 1200 mg 24 0.3 High
 Chevalley et al. (43) 2005 Switzerland 174 89.3 850 mg 12 0.2 High
 Courteix et al. 1 (44) 2005 France 54 119.3 800 mg 12 — High
 Courteix et al. 2 (44) 2005 France 31 119.3 800 mg 12 — High
 Dibba et al. (45) 2000 Gambia 160 124 714.3 mg 12 −1.09 High
 Ekbote et al. (46) 2011 India 58 33 357.1 mg 12 −1.96 High
 Iuliano-Burns et al. 1 (47) 2003 Australia 34 106 434 mg 9 −0.08 High
 Iuliano-Burns et al. 2 (47) 2003 Australia 32 106 434 mg 9 0.27 High
 Lloyd et al. (48) 1993 United States 94 143 500 mg 18 −0.23 High
 Nowson et al. (49) 1997 Australia 56 168 1000 mg 18 −0.9 High
 Pettifor et al. (50) 1981 South Africa 60 121 500 mg 3 −1.09 Medium
 Specker and Binkley 1 (51) 2003 United States 90 48 714.3 mg 12 0 High
 Specker and Binkley 2 (51) 2003 United States 88 39 714.3 mg 12 −0.15 High
Iodine
 Zimmerman et al. 1 (52) 2007 Albania 310 137 400 mg2 6 −1.13 Medium
 Zimmerman et al. 2 (52) 2007 South Africa 188 110 200 mg3 6 −0.54 Medium
Vitamin A
 Fawzi et al. 1 (53) 1997 Sudan 2166 24 to <364 200,000 IU 17 — High
 Fawzi et al. 2 (53) 1997 Sudan 2033 36 to <484 200,000 IU 17 — High
 Fawzi et al. 3 (53) 1997 Sudan 1975 48 to <604 200,000 IU 17 — High
 Fawzi et al. 4 (53) 1997 Sudan 1756 60 to <724 200,000 IU 17 — High
 Fawzi et al. 5 (53) 1997 Sudan 2079 >604 200,000 IU 17 — High
 Fawzi et al. 6 (53) 1997 Sudan 1991 24 to <364 200,000 IU 17 — High
 Fawzi et al. 7 (53) 1997 Sudan 2023 36 to <484 200,000 IU 17 — High
 Fawzi et al. 8 (53) 1997 Sudan 1985 48 to <604 200,000 IU 17 — High
 Fawzi et al. 9 (53) 1997 Sudan 1875 60 to <724 200,000 IU 17 — High
 Fawzi et al. 10 (53) 1997 Sudan 2120 >604 200,000 IU 17 — High
 Hadi et al. 1 (54) 2000 Indonesia 377 ≥244 206,000 IU 24 — Medium
 Hadi et al. 2 (54) 2000 Indonesia 2263 ≥244 206,000 IU 24 — Medium
 Lin et al. (55) 2009 China 86 37 100,000 IU 3 −0.46 High
 Mwanri et al. 1(19) 2000 Tanzania 68 131 5000 IU 3 −2.13 High
 Mwanri et al. 2 (19) 2000 Tanzania 68 127 5000 IU 3 −1.39 High
 Yang et al. (56) 2002 China 63 48 667 IU 12 −1.55 High
1

bw, body weight; HAZ, height-for-age z score; IU, international unit.

2

Single dose.

3

Two doses delivered 3 mo apart.

4

Age range.