TABLE 1.

Baseline study characteristics of single-micronutrient interventions in children ≥2 y of age¹

Study	Year	Country	Subjects, n	Mean initial age, mo	Dose	Duration, mo	Mean initial HAZ	Quality
Iron
Aguayo (10)	2000	Bolivia	64	111	3 mg/kg bw	4	−1.48	High
Angeles et al. (11)	1993	Indonesia	76	37	30 mg	2	−2.26	Medium
Bhatia and Seshadri 1 (12)	1992	India	105	47	40 mg	6	−2.3	Medium
Bhatia and Seshadri 2 (12)	1992	India	51	54	40 mg	6	−1.56	Medium
Chen et al. (13)	2008	China	132	48	8.57 mg	6	−0.23	Medium
Chwang et al. (14)	1988	Indonesia	41	128	10 mg/kg bw	3	−1.52	Medium
Dossa et al. (15)	2001	Benin	68	47	60 mg	3	−2.26	Medium
Hettiarachchi et al. (16)	2008	Sri Lanka	374	167	35.71 mg	6	−1.19	Medium
Latham et al. (17)	1990	Kenya	55	96	285.7 mg	1	−0.88	High
Lawless et al. (18)	1994	Kenya	86	105	150 mg	3	−1.23	High
Mwanri et al. 1 (19)	2000	Tanzania	68	132	85.7 mg	3	−2.2	High
Mwanri et al. 2 (19)	2000	Tanzania	68	126	85.7 mg	3	−1.56	High
Palupi et al. (20)	1997	Indonesia	187	42	4.29 mg	2	−1.82	Medium
Pereira et al. (21)	1979	India	44	42	10 mg	5	—	Low
Rahman et al. (22)	1999	Bangladesh	147	34	15 mg	12	−2.2	High
Sungthong et al. 1 (23)	2002	Thailand	200	116	300 mg	4	−1.55	High
Sungthong et al. 2 (23)	2002	Thailand	190	116	42.86 mg	4	−1.49	High
Zinc
Castillo-Durán et al. 1 (24)	1994	Chile	19	169	10 mg	12	−2.58	High
Castillo-Durán et al. 2 (24)	1994	Chile	18	138	10 mg	12	−2.61	High
Cavan et al. (25)	1993	Guatemala	156	82	7.14 mg	6	−1.38	High
Friis et al. (26)	1997	Zimbabwe	276	134	40 mg	12	−1.18	High
Gibson et al. (27)	1989	Canada	60	75	10 mg	12	−1.39	High
Hettiarachchi et al. (16)	2008	Sri Lanka	382	161	10 mg	6	−1.1	High
Kaseb and Fallah (28)	2013	Iran	95	146	5 mg	4	−0.6	High
Kikafunda et al. (29)	1998	Uganda	113	56	10 mg	6	−0.7	High
Mozaffari-Khosravi et al. 1 (30)	2009	Iran	47	39	5 mg	6	−1.58	Medium
Mozaffari-Khosravi et al. 2 (30)	2009	Iran	38	40	5 mg	6	−1.65	Medium
Nakamura et al. (31)	1993	Japan	21	70	5 mg	6	−2.44	Low
Ronaghy et al. (32)	1969	Iran	27	156	28 mg	5	−2.73	Low
Ronaghy et al. (33)	1974	Iran	39	156	40 mg	12	−3.02	Low
Rosado et al. (34)	1997	Mexico	95	29	20 mg	12	−1.7	High
Ruz et al. (35)	1997	Chile	53	40	10 mg	14	−0.52	High
Sayeg Porto et al. (36)	2000	Brazil	18	116	5 mg/kg bw	6	−2.67	Medium
Sempértegui et al. (37)	1996	Ecuador	48	42	10 mg	2	−2	High
Taneja et al. (38)	2010	India	421	27	20 mg	4	—	High
Walravens et al. (39)	1983	United States	40	50	10 mg	12	−2.07	High
Calcium
Bass et al. 1 (40)	2007	Australia	47	109	800 mg	9	0.47	High
Bass et al. 2 (40)	2007	Australia	41	109	800 mg	9	0.36	High
Bonjour et al. (41)	1997	Switzerland	108	95	850 mg	12	0.3	High
Cameron et al. (42)	2004	Australia	48	124	1200 mg	24	0.3	High
Chevalley et al. (43)	2005	Switzerland	174	89.3	850 mg	12	0.2	High
Courteix et al. 1 (44)	2005	France	54	119.3	800 mg	12	—	High
Courteix et al. 2 (44)	2005	France	31	119.3	800 mg	12	—	High
Dibba et al. (45)	2000	Gambia	160	124	714.3 mg	12	−1.09	High
Ekbote et al. (46)	2011	India	58	33	357.1 mg	12	−1.96	High
Iuliano-Burns et al. 1 (47)	2003	Australia	34	106	434 mg	9	−0.08	High
Iuliano-Burns et al. 2 (47)	2003	Australia	32	106	434 mg	9	0.27	High
Lloyd et al. (48)	1993	United States	94	143	500 mg	18	−0.23	High
Nowson et al. (49)	1997	Australia	56	168	1000 mg	18	−0.9	High
Pettifor et al. (50)	1981	South Africa	60	121	500 mg	3	−1.09	Medium
Specker and Binkley 1 (51)	2003	United States	90	48	714.3 mg	12	0	High
Specker and Binkley 2 (51)	2003	United States	88	39	714.3 mg	12	−0.15	High
Iodine
Zimmerman et al. 1 (52)	2007	Albania	310	137	400 mg2	6	−1.13	Medium
Zimmerman et al. 2 (52)	2007	South Africa	188	110	200 mg3	6	−0.54	Medium
Vitamin A
Fawzi et al. 1 (53)	1997	Sudan	2166	24 to <364	200,000 IU	17	—	High
Fawzi et al. 2 (53)	1997	Sudan	2033	36 to <484	200,000 IU	17	—	High
Fawzi et al. 3 (53)	1997	Sudan	1975	48 to <604	200,000 IU	17	—	High
Fawzi et al. 4 (53)	1997	Sudan	1756	60 to <724	200,000 IU	17	—	High
Fawzi et al. 5 (53)	1997	Sudan	2079	>604	200,000 IU	17	—	High
Fawzi et al. 6 (53)	1997	Sudan	1991	24 to <364	200,000 IU	17	—	High
Fawzi et al. 7 (53)	1997	Sudan	2023	36 to <484	200,000 IU	17	—	High
Fawzi et al. 8 (53)	1997	Sudan	1985	48 to <604	200,000 IU	17	—	High
Fawzi et al. 9 (53)	1997	Sudan	1875	60 to <724	200,000 IU	17	—	High
Fawzi et al. 10 (53)	1997	Sudan	2120	>604	200,000 IU	17	—	High
Hadi et al. 1 (54)	2000	Indonesia	377	≥244	206,000 IU	24	—	Medium
Hadi et al. 2 (54)	2000	Indonesia	2263	≥244	206,000 IU	24	—	Medium
Lin et al. (55)	2009	China	86	37	100,000 IU	3	−0.46	High
Mwanri et al. 1(19)	2000	Tanzania	68	131	5000 IU	3	−2.13	High
Mwanri et al. 2 (19)	2000	Tanzania	68	127	5000 IU	3	−1.39	High
Yang et al. (56)	2002	China	63	48	667 IU	12	−1.55	High

¹bw, body weight; HAZ, height-for-age z score; IU, international unit.

²Single dose.

³Two doses delivered 3 mo apart.

⁴Age range.