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. 2017 Mar 9;8:14749. doi: 10.1038/ncomms14749

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Copyright © 2017, The Author(s)

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(a) Quantified GFP fluorescence intensity of an NMD reporter, sec-23p::gfp::lacZ(PTC) (lacZ(PTC)), upon knockdown of smg genes (n=16 from two independent experiments). Error bars represent s.e.m. (two-tailed Student's t-test, **P<0.01, ***P<0.001). (b–f) RNAi knockdown of each NMD component, smg-1 (b), smg-2 (c), smg-3 (d), smg-4 (one out of two trials) (e) or smg-5 (f), shortened the longevity of daf-2(e1370) (daf-2(−)) mutants. See Supplementary Data 1 for statistical analysis and additional repeats.