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. Author manuscript; available in PMC: 2018 Jan 15.
Published in final edited form as: Int J Cardiol. 2016 Oct 24;227:808–812. doi: 10.1016/j.ijcard.2016.10.055

Table 2.

Baseline Characteristics According to Stroke Severity

Characteristics Overall (n = 1030) Severe stroke (n = 711) Not-Severe Stroke (n = 319) P value
Severe Stroke vs Not-Severe Stroke
Women, No. (%) 576 (55.9) 425 (59.8) 151 (47.3) <0.001
White race, No. (%) 764 (74.2) 544 (76.5) 220 (69.0) 0.011
Age, mean (±SD), years 77.0 (±11.1) 78.8 (±10.5) 73.2 (±11.6) < .0001
AF Type, No. (%)
 New Onset 258 (25.0) 170 (23.9) 88 (27.6)
 Paroxysmal 250 (24.3) 157 (22.1) 93 (29.2) 0.005
 Permanent 522 (50.7) 384 (54.0) 138 (43.3)
Congestive heart failure, No. (%) 349 (33.9) 258 (36.3) 91 (28.5) 0.015
Hypertension, No. (%) 934 (90.7) 648 (91.1) 286 (89.7) 0.45
Diabetes mellitus, No. (%) 395 (38.3) 282 (39.7) 113 (35.4) 0.20
Prior ischemic stroke, No. (%) 278 (27.0) 208 (29.3) 70 (21.9) 0.015
Peripheral vascular disease, No. (%) 107 (10.4) 77 (10.8) 30 (9.4) 0.49
Coronary artery disease, No. (%) 403 (39.0) 284 (39.9) 118 (37.0) 0.37
Chronic kidney disease, No. (%) 192 (18.6) 147 (20.7) 45 (14.1) 0.012
Prior deep venous thrombosis or pulmonary embolism, No. (%) 102 (9.9) 81 (11.4) 21 (6.6) 0.017
Dementia, No. (%) 154 (15.0) 135 (19.0) 19 (6.0) < .0001
Smoking status
 Current smoker, No. (%) 110 (10.7) 66 (9.2) 44 (13.8) 0.041
 Nonsmoker, No. (%) 878 (85.2) 611 (85.9) 267 (83.7)
 Unknown, No. (%) 42 (4.1) 34 (4.8) 8 (2.5)
Active malignancy, No. (%) 108 (10.5) 78 (11.0) 30 (9.4) 0.45
CHA2DS2VASc
 Mean score (SD) 4.8 (1.8) 5.0 (1.7) 4.3 (1.8) < .0001
 Score, No. (%)
  0 – 1 38 (3.7) 16 (2.3) 22 (6.9)
  2 61 (5.9) 29 (4.1) 32 (10.0)
  3 134 (13.0) 89 (12.5) 45 (14.1)
  4 214 (20.8) 140 (19.7) 74 (23.2)
  5 219 (21.3) 154 (21.7) 65 (20.4) < .0001
  6 191 (18.5) 142 (20.0) 49 (15.4)
  7 106 (10.3) 85 (12.0) 21 (6.6)
  8 53 (5.1) 45 (6.3) 8 (2.5)
  9 14 (1.4) 11 (1.5) 3 (0.9)
Warfarin use, No. (%) 292 (28.3) 206 (29.0) 86 (27.0) 0.51
Admission INR
 Median (IQR) 1.6 (1.2 – 2.3) 2.0 (1.3 – 2.4) 1.8 (1.2 – 2.2) 0.13
Statin use, No (%) 400 (38.8) 260 (36.6) 140 (43.9) 0.026

SD: standard deviation; CHA2DS2VASc: a risk assessment tool for stroke in patients with AF which assigns 1 point for congestive heart failure, 1 point for hypertension, 2 points for age 75 years or older, 1 point for diabetes mellitus, 2 points for history of stroke or transient ischemic attack, 1 point for vascular disease including prior myocardial infarction or peripheral arterial disease, 1 point for age 65 to 74 years, and 1 point for female sex; INR: international normalized ratio; IQR: interquartile range