Table 3. Meta-analysis of the association between high Ki-67 expression and clinicopathological features of RCC.
| Variables | Studies | Pooled RR | 95% CI | P Value | Model | Heterogeneity I2 (%) | P Value |
|---|---|---|---|---|---|---|---|
| TNM stage (III/IV vs. I/II) | 4 | 2.03 | 1.68–2.44 | <0.001 | fixed | 18.2 | 0.300 |
| pT stage (T3/T4 vs. T1/T2) | 8 | 1.67 | 1.35–2.06 | <0.001 | random | 58.5 | 0.018 |
| Metastasisa (yes vs. no) | 5 | 2.15 | 1.77–2.62 | <0.001 | fixed | 15.9 | 0.313 |
| Fuhrman grade (III/IV vs. I/II) | 8 | 1.77 | 1.20–2.60 | 0.004 | random | 95.2 | <0.001 |
aBoth lymph node and distant metastases; RR: relative ratio; CI: confidence interval; RCC: renal cell carcinoma.