Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Synthesis of the linear trimer and macrocyclization step. Reagents and conditions: (i) EDCI, HOBt, DIEA, DMF (70%); (ii) H2/Pd-C (10%); (iii) 8b, EDCI, HOBt, DIEA, DMF (60%, two steps); (iv) H2/Pd-C (10%); (v) C6F5OH, N,N-dicyclohexylcarbodiimide, DCM; (vi) TFA, DCM, RT, 3 h (82%, three steps); (vii) DMAP, toluene, 95°C (72%).
