FIG 2 .

IL-25 prevents E. histolytica infection and development of colitis in the mouse model. (A to C) Mice were injected intraperitoneally with 0.5 µg recombinant IL-25 (red bar or solid red triangle) or PBS (black bar or open circle) each day for 8 days and were challenged with E. histolytica on day 5. Cecal contents were harvested 7 days after E. histolytica challenge (day 12), and parasite infection was evaluated by culture (A), E. histolytica antigen detection (B), and E. histolytica DNA (C). (D) Representative cecal histopathology of E. histolytica-challenged mice with or without IL-25 treatment. (E) Epithelial disruption score in E. histolytica challenged with or without rIL-25. *, P < 0.05.