Table 2. Gb3 levels in organs from Fabry mice euthanized 28 weeks after neonatal injection.
| Gb3, nmol/mg of protein
|
|||||
|---|---|---|---|---|---|
| Injection | Liver | Spleen | Lung | Heart | Kidney |
| α-Gal A (n = 12) | 0.8 ± 0.5* | 7.5 ± 2.1* | 2.2 ± 0.2 | 1.0 ± 0.2* | 24.0 ± 2.7 |
| D-PBS (n = 4) | 4.3 ± 1.2 | 64.2 ± 9.6 | 2.5 ± 0.2 | 2.8 ± 0.4 | 26.4 ± 5.2 |
| WT (n = 5) | 0.1 ± 0.0 | 0.0 ± 0.0 | 0.1 ± 0.0 | 0.1 ± 0.1 | 1.8 ± 0.5 |
α-Gal A, LV/α-Gal A-huCD25-injected group. *, P < 0.05 vs. D-PBS group.