Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Mar 13;7:44450. doi: 10.1038/srep44450

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2017, The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

PMC Copyright notice

(A) Average 16 kHz ABR thresholds (±standard deviations) of 3-month-old 129 S1 inbred strain mice (N = 10), 129S1.B6-Cdh23^ahlcongenic mice (Congenic; N = 10), 129S-Cdh23^c.753A mice (SNV; N = 19), and (Congenic × SNV) F1 hybrids (N = 6). (B) Frequency distribution of 16 kHz ABR thresholds among 3-month-old N2 mice (N = 182) from a backcross of (129S-Cdh23^c.753A SNV × 129S1.B6-Cdh23^ahl congenic) F1 hybrids with 129S-Cdh23^c.753A SNV mice. The threshold ranges and averages of age-matched parental strain mice (F1 hybrids, SNV mice) are indicated at the top of the figure as horizontal gray lines. N2 mice with homozygous and heterozygous Mahl genotypes are distinguished by red and blue colors. (C) Chr 10 haplotype analysis of N2 mice. SNP markers and their Mb positions along Chr 10 are shown above the corresponding genotypes of parental strain and N2 backcross mice. Haplotypes C and D contain crossovers within the congenic region, and the correlations of ABR thresholds with SNP genotypes further refine the candidate region of the modifier locus (designated Mahl). The 129S1.B6-Cdh23^ahlcongenic region and the Mahl candidate gene region are indicated by dotted lines. The non-recombinant rs13480621 and Cdh23^c.753A markers were used to assign Mahl genotypes in panel B above. Allele designations: B, C57BL/6-derived; S, 129S1-derived; S*, 129S1-derived with targeted Cdh23^c.753G>A substitution.