Table 3.
Estimates of Association with Chronic Periodontitis and SNP Information among the ARIC European-American and African-American Samples for the 5 Loci Prioritized (P < 5 × 10−6) from the HCHS/SOL Discovery.
| European American (n = 4,402)a |
African American (n = 908)a |
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Region | SNP | g/ib | b | P Value | MAF | Oevarc | g/ib | b | P Value | MAF | Oevarc |
| 1q22 | rs13373934 | i | Monod | i | 0.049 | 4.0 × 10−2 | G, 0.029 | 0.969 | |||
| 1q42.2 | rs149133391 | i | 0.040 | 3.2 × 10−1 | C, 0.004 | 0.595 | i | −0.124 | 9.1 × 10−3 | C, 0.019 | 0.444 |
| 5p15.33 | rs186066047 | i | Monod | i | 0.023 | 4.7 × 10−1 | A, 0.019 | 0.823 | |||
| 6p22.3 | rs10456847 | i | −0.007 | 8.5 × 10−2 | G, 0.460 | 1.000 | i | −0.007 | 4.4 × 10−1 | G, 0.222 | 1.000 |
| 11p15.1 | rs75715012 | i | −0.001 | 9.0 × 10−1 | A, 0.099 | 0.988 | i | −0.001 | 9.6 × 10−1 | A, 0.148 | 0.943 |
Chronic periodontitis: mean interproximal attachment loss continuous trait.
ARIC, Atherosclerosis Risk in Communities; HCHS/SOL, Hispanic Community Health Study / Study of Latinos; MAF, minor allele frequency; SNP, single-nucleotide polymorphism.
Results based on linear regression modeling of mean interproximal attachment loss (cubic root transformation) adjusting for 10 ancestry principal components, age, sex, examination center, and smoking (never/former/current); the analytic sample numbers reflect the exclusion of 253 European-American and 4 African-American ARIC participants due to missing covariates.
Genotyped or imputed SNP.
Imputation quality metric based on the observed to expected dosage variance ratio after imputation.
Monomorphic.