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. Author manuscript; available in PMC: 2018 Apr 1.
Published in final edited form as: Int Ophthalmol Clin. 2017 Spring;57(2):109–118. doi: 10.1097/IIO.0000000000000169

Table.

Comparisons between mouse model and human dry eye disease

Disease marker/parameter Therapeutic response Mouse Model Human Dry Eye Disease
Increased innate
inflammatory mediators
(cytokines, chemokines,
MMPs)		 10–12 19–21
Increased ICAM1 expression
in lacrimal gland and
conjunctiva		 22,23 24
Increased epithelial
apoptosis		 1,25 26
Conjunctival goblet cell loss 15,27 28,29
Dendritic cell maturation 14 30,31
CD4 T cell infiltration 15,32 33
Increased Th cytokines 15,16 29
Improved corneal barrier
with corticosteroids		 34 35–37
Improved conjunctival goblet
cells with cyclosporine		 38 39,40

The numbers in the table refer to relevant references.