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. 2017 Feb 22;114(10):2729–2734. doi: 10.1073/pnas.1613635114

Fig. 3.

Fig. 3.

Exogenous addition of dNs has a different impact on HIV-1 infection in resting CD4 T cells and macrophages. (A) Resting CD4 T cells were challenged with equal infectious units of X4 HIV-1*GFP virions with or without (no Vpx) incorporated Vpx from SIVmac239, SIVmnd-2, or SIVrcm in the presence or absence of 2 mM dNTP precursors (dNs) and analyzed on day 3 postinfection for GFP expression and SAMHD1 levels. The percentages of GFP+ cells are shown for one representative donor out of three. (B) MDMs were challenged with equal infectious units of VSV-G pseudotyped HIV-1*GFP virions with or without (no Vpx) incorporated Vpx from SIVmac239, SIVmnd-2, or SIVrcm in the presence or absence of 4 mM dNs and analyzed on day 3 postinfection for GFP expression and SAMHD1 levels. The arithmetic means + SEM of four donors are depicted for the percentage of GFP+ cells.