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. 2017 Feb 22;114(10):E1933–E1940. doi: 10.1073/pnas.1621082114

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Fig. 4. — Modeling of CYP11B1 mutations harbored by compound heterozygotes. The following mutations were modeled: R141Q (A); T319M (B); G444D (C); R43Q (D); A386V (E); L407F (F); V441G (G); N133H (H); R138C (I); E198G (J); S288R (K); A368D (L); R453Q (M); and R453W (N). (O) The change (∆∆G kcal/mol) in protein stability upon mutation of each residue. The disks represent the pairwise atomic van der Waals radii overlap. Green disks represent almost in contact or slightly overlapping, and red disks represent significant overlap.