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. 2017 Feb 14;114(10):2610–2615. doi: 10.1073/pnas.1616816114

Fig. 6.

Fig. 6.

Structures and models of wild-type and modified NALs. Structures of (A) wild-type (PDB ID code 4AH7) (34) and (B) Phe190Dpc (PDB ID code 5LKY) NAL enzymes in complex with pyruvate were structurally aligned. B shows the network of interactions that the Nca side chain Dpc forms with Asp141 and Glu192. Energy-minimized models of product Schiff base structures [illustrated with 4(S)-DHA] were generated using Maestro and are displayed from the same view. (C) Wild-type NAL. (D) Phe190Dpc enzyme complex.