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Comparison of Pro169-Ala168-Thr167 chain in the wild-type (cyan) NAL and Phe190Dpc (magenta) NAL crystal structures. The replacement of Phe190 by Dpc results in a movement of this part of the protein backbone brings Thr167 1.0 ± 0.1 Å deeper into the active site where it adopts a different rotamer compared with the wild-type structure.
