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Summary of In Vitro Cross-Resistance for Hepatitis B Virus Variants
| HBV variant | Lamivudine | Entecavir | Adefovir | Tenofovir |
|---|---|---|---|---|
| Wild-type | S | S | S | S |
| M204V/I | R | I | I | S |
| L180M+M204V | R | I | I | S |
| A181T/V | R | S | R | S |
| N236T | S | S | R | I |
| A181T/V+N236T | R | S | R | I |
| L180M+M204V/I±T184 | R | R | S | S |
| L180M+M204V/I±S202 | R | R | S | S |
| L180M+M204V/I±I169T±M250 | R | R | S | S |
HBV, hepatitis B virus; S, sensitive; I, intermediate/reduced susceptibility; R, resistant.
