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. 2016 Sep 10;7(50):81981–81994. doi: 10.18632/oncotarget.11962

Figure 1. Identification and transcriptional regulation of LINC00520 in a model of Src-induced transformation of mammary epithelial cells.

Figure 1

a. Heat maps showing subset of protein coding genes and long non-coding RNAs that are differentially expressed at 4,12 and 36 hours post Src induction, in MCF10A cells. b. RNA Sequencing, relative expression of LINC00520 at various time-points post Src induction in immortalized mammary epithelial MCF10A cells. FPKM, fragments per kilobase of transcript per million mapped reads. c. STAT3 ChIP enrichment in MCF10A cells post Src induction, at the LINC00520 locus. d. Expression of LINC00520 following siRNA-mediated depletion of STAT3 in MCF10A-Src transformed cells. Transcript levels were determined by qRT-PCR and normalized to GAPDH. Values represent the average of three technical triplicates.