Table 2. Genetic models analyses of the association between CDKN2BAS SNPs and CHD susceptibility in men and women.
| SNP-ID | Model | Genotype | Men | Women | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Case | Control | OR (95% CI) | P-value | Case | Control | OR (95% CI) | P-value | |||
| rs7865618 | Codominant | A/A | 227 (78.3%) | 290 (75.3%) | 1 | 127 (77%) | 240 (80%) | 1 | 0.021 | |
| G/A | 59 (20.3%) | 88 (22.9%) | 0.80 (0.52-1.23) | 0.430 | 30 (18.2%) | 57 (19%) | 1.07 (0.57-1.98) | |||
| G/G | 4 (1.4%) | 7 (1.8%) | 0.54 (0.13-2.18) | 8 (4.8%) | 3 (1%) | 8.20 (1.76-38.35) | ||||
| Dominant | A/A | 227 (78.3%) | 290 (75.3%) | 1 | 127 (77%) | 240 (80%) | 1 | |||
| G/A-G/G | 63 (21.7%) | 95 (24.7%) | 0.78 (0.52-1.18) | 0.240 | 38 (23%) | 60 (20%) | 1.37 (0.77-2.45) | 0.290 | ||
| Recessive | A/A-G/A | 286 (98.6%) | 378 (98.2%) | 1 | 157 (95.2%) | 297 (99%) | 1 | |||
| G/G | 4 (1.4%) | 7 (1.8%) | 0.57 (0.14-2.28) | 0.420 | 8 (4.8%) | 3 (1%) | 8.10 (1.74-37.68) | 0.006 | ||
| Log-additive | --- | --- | --- | 0.78 (0.54-1.14) | 0.200 | --- | --- | 1.58 (0.97-2.58) | 0.068 | |
| rs11790231 | Codominant | G/G | 217 (74.6%) | 281 (73.6%) | 1 | 121 (73.3%) | 208 (69.3%) | 1 | 0.520 | |
| A/G | 62 (21.3%) | 95 (24.9%) | 0.99 (0.65-1.50) | 0.380 | 39 (23.6%) | 86 (28.7%) | 0.74 (0.42-1.29) | |||
| A/A | 12 (4.1%) | 6 (1.6%) | 2.15 (0.71-6.52) | 5 (3%) | 6 (2%) | 1.23 (0.28-5.36) | ||||
| Dominant | G/G | 217 (74.6%) | 281 (73.6%) | 1 | 121 (73.3%) | 208 (69.3%) | 1 | |||
| A/G-A/A | 74 (25.4%) | 101 (26.4%) | 1.07 (0.72-1.60) | 0.720 | 44 (26.7%) | 92 (30.7%) | 0.78 (0.45-1.33) | 0.350 | ||
| Recessive | G/G-A/G | 279 (95.9%) | 376 (98.4%) | 1 | 160 (97%) | 294 (98%) | 1 | |||
| A/A | 12 (4.1%) | 6 (1.6%) | 2.15 (0.71-6.51) | 0.160 | 5 (3%) | 6 (2%) | 1.33 (0.31-5.76) | 0.700 | ||
| Log-additive | --- | --- | --- | 1.14 (0.81-1.60) | 0.450 | --- | --- | 0.85 (0.53-1.35) | 0.490 | |
| rs1412832 | Codominant | T/T | 161 (55.5%) | 194 (50.5%) | 1 | 84 (50.9%) | 153 (51%) | 1 | 0.760 | |
| T/C | 108 (37.2%) | 161 (41.9%) | 0.76 (0.52-1.09) | 0.250 | 72 (43.6%) | 123 (41%) | 1.02 (0.62-1.69) | |||
| C/C | 21 (7.2%) | 29 (7.5%) | 0.70 (0.36-1.37) | 9 (5.5%) | 24 (8%) | 0.71 (0.27-1.90) | ||||
| Dominant | T/T | 161 (55.5%) | 194 (50.5%) | 1 | 84 (50.9%) | 153 (51%) | 1 | |||
| T/C-C/C | 129 (44.5%) | 190 (49.5%) | 0.75 (0.53-1.06) | 0.100 | 81 (49.1%) | 147 (49%) | 0.97 (0.60-1.57) | 0.890 | ||
| Recessive | T/T-T/C | 269 (92.8%) | 355 (92.5%) | 1 | 156 (94.5%) | 276 (92%) | 1 | |||
| C/C | 21 (7.2%) | 29 (7.5%) | 0.79 (0.42-1.51) | 0.480 | 9 (5.5%) | 24 (8%) | 0.70 (0.27-1.83) | 0.470 | ||
| Log-additive | --- | --- | --- | 0.80 (0.61-1.05) | 0.110 | --- | --- | 0.92 (0.63-1.36) | 0.680 | |
| rs6475606 | Codominant | T/T | 156 (53.6%) | 183 (47.7%) | 1 | 77 (46.7%) | 146 (48.7%) | 1 | 0.920 | |
| C/T | 110 (37.8%) | 169 (44%) | 0.73 (0.50-1.05) | 0.210 | 76 (46.1%) | 130 (43.3%) | 0.91 (0.55-1.50) | |||
| C/C | 25 (8.6%) | 32 (8.3%) | 0.76 (0.40-1.43) | 12 (7.3%) | 24 (8%) | 0.89 (0.36-2.23) | ||||
| Dominant | T/T | 156 (53.6%) | 183 (47.7%) | 1 | 77 (46.7%) | 146 (48.7%) | 1 | |||
| C/T-C/C | 135 (46.4%) | 201 (52.3%) | 0.73 (0.52-1.04) | 0.077 | 88 (53.3%) | 154 (51.3%) | 0.90 (0.56-1.47) | 0.680 | ||
| Recessive | T/T-C/T | 266 (91.4%) | 352 (91.7%) | 1 | 153 (92.7%) | 276 (92%) | 1 | |||
| C/C | 25 (8.6%) | 32 (8.3%) | 0.88 (0.48-1.61) | 0.670 | 12 (7.3%) | 24 (8%) | 0.94 (0.39-2.27) | 0.880 | ||
| Log-additive | --- | --- | --- | 0.81 (0.62-1.06) | 0.120 | --- | --- | 0.93 (0.63-1.36) | 0.700 | |
| rs1333040 | Codominant | T/T | 156 (53.6%) | 188 (49.1%) | 1 | 80 (48.5%) | 148 (49.3%) | 1 | 0.930 | |
| T/C | 111 (38.1%) | 165 (43.1%) | 0.78 (0.54-1.12) | 0.380 | 73 (44.2%) | 128 (42.7%) | 0.91 (0.55-1.52) | |||
| C/C | 24 (8.2%) | 30 (7.8%) | 0.81 (0.43-1.55) | 12 (7.3%) | 24 (8%) | 0.90 (0.36-2.24) | ||||
| Dominant | T/T | 156 (53.6%) | 188 (49.1%) | 1 | 80 (48.5%) | 148 (49.3%) | 1 | |||
| T/C-C/C | 135 (46.4%) | 195 (50.9%) | 0.78 (0.55-1.11) | 0.170 | 85 (51.5%) | 152 (50.7%) | 0.91 (0.56-1.48) | 0.710 | ||
| Recessive | T/T-T/C | 267 (91.8%) | 353 (92.2%) | 1 | 153 (92.7%) | 276 (92%) | 1 | |||
| C/C | 24 (8.2%) | 30 (7.8%) | 0.91 (0.49-1.69) | 0.760 | 12 (7.3%) | 24 (8%) | 0.94 (0.39-2.27) | 0.880 | ||
| Log-additive | --- | --- | --- | 0.85 (0.65-1.11) | 0.230 | --- | --- | 0.93 (0.64-1.37) | 0.720 | |
| rs1537370 | Codominant | T/T | 156 (53.6%) | 185 (48%) | 1 | 77 (46.7%) | 146 (48.7%) | 1 | 0.920 | |
| C/T | 111 (38.1%) | 170 (44.2%) | 0.73 (0.51-1.06) | 0.240 | 76 (46.1%) | 130 (43.3%) | 0.91 (0.55-1.50) | |||
| C/C | 24 (8.2%) | 30 (7.8%) | 0.79 (0.41-1.51) | 12 (7.3%) | 24 (8%) | 0.89 (0.36-2.23) | ||||
| Dominant | T/T | 156 (53.6%) | 185 (48%) | 1 | 77 (46.7%) | 146 (48.7%) | 1 | |||
| C/T-C/C | 135 (46.4%) | 200 (52%) | 0.74 (0.53-1.05) | 0.093 | 88 (53.3%) | 154 (51.3%) | 0.90 (0.56-1.47) | 0.680 | ||
| Recessive | T/T-C/T | 267 (91.8%) | 355 (92.2%) | 1 | 153 (92.7%) | 276 (92%) | 1 | |||
| C/C | 24 (8.2%) | 30 (7.8%) | 0.91 (0.49-1.70) | 0.760 | 12 (7.3%) | 24 (8%) | 0.94 (0.39-2.27) | 0.880 | ||
| Log-additive | --- | --- | --- | 0.82 (0.62-1.07) | 0.150 | --- | --- | 0.93 (0.63-1.36) | 0.700 | |
| rs10757274 | Codominant | A/A | 82 (28.2%) | 130 (33.8%) | 1 | 39 (23.6%) | 102 (34%) | 1 | 0.004 | |
| A/G | 137 (47.1%) | 188 (48.8%) | 1.16 (0.78-1.72) | 0.042 | 101 (61.2%) | 141 (47%) | 2.60 (1.44-4.71) | |||
| G/G | 72 (24.7%) | 67 (17.4%) | 1.86 (1.13-3.05) | 25 (15.2%) | 57 (19%) | 1.52 (0.72-3.23) | ||||
| Dominant | A/A | 82 (28.2%) | 130 (33.8%) | 1 | 39 (23.6%) | 102 (34%) | 1 | |||
| A/G-G/G | 209 (71.8%) | 255 (66.2%) | 1.33 (0.91-1.93) | 0.130 | 126 (76.4%) | 198 (66%) | 2.26 (1.28-3.99) | 0.004 | ||
| Recessive | A/A-A/G | 219 (75.3%) | 318 (82.6%) | 1 | 140 (84.8%) | 243 (81%) | 1 | |||
| G/G | 72 (24.7%) | 67 (17.4%) | 1.70 (1.10-2.62) | 0.016 | 25 (15.2%) | 57 (19%) | 0.81 (0.43-1.51) | 0.500 | ||
| Log-additive | --- | --- | --- | 1.34 (1.05-1.71) | 0.019 | --- | --- | 1.31 (0.92-1.87) | 0.130 | |
| rs1333042 | Codominant | G/G | 139 (47.9%) | 162 (42.6%) | 1 | 74 (44.9%) | 130 (43.3%) | 1 | 0.810 | |
| G/A | 122 (42.1%) | 168 (44.2%) | 0.88 (0.61-1.27) | 0.120 | 75 (45.5%) | 136 (45.3%) | 0.87 (0.52-1.45) | |||
| A/A | 29 (10%) | 50 (13.2%) | 0.55 (0.31-0.97) | 16 (9.7%) | 34 (11.3%) | 0.81 (0.36-1.84) | ||||
| Dominant | G/G | 139 (47.9%) | 162 (42.6%) | 1 | 74 (44.9%) | 130 (43.3%) | 1 | |||
| G/A-A/A | 151 (52.1%) | 218 (57.4%) | 0.79 (0.56-1.12) | 0.190 | 91 (55.1%) | 170 (56.7%) | 0.86 (0.53-1.39) | 0.530 | ||
| Recessive | G/G-G/A | 261 (90%) | 330 (86.8%) | 1 | 149 (90.3%) | 266 (88.7%) | 1 | |||
| A/A | 29 (10%) | 50 (13.2%) | 0.59 (0.34-1.01) | 0.050 | 16 (9.7%) | 34 (11.3%) | 0.87 (0.40-1.90) | 0.730 | ||
| Log-additive | --- | --- | --- | 0.78 (0.61-1.01) | 0.058 | --- | --- | 0.89 (0.62-1.28) | 0.530 | |
OR: Odd ratio; 95% CI: 95% Confidence.
P values were calculated from the Wald test.
P < 0.05 indicates statistical significance.