Table 2. Clinicopathological features and methylation at two regions of RECK CpG island (RPM and RIM) in breast cancer tissues.

			n	RPM				RIM
				Number		Ratio	P	Number		Ratio	P
				+	−	RPM+/n (%)		+	−	RIM+/n (%)
Total			62	16	46	26		33	29	53
Age	<55		20	4	16	20	NS (0.47)	10	10	50	NS (0.73)
	>55		42	12	30	29		23	19	55
Subtype	DCIS		6	0	6	0	NS (0.13)	0	6	0	0.00014
	Lum (ER+)	PR+	28	9	19	32		16	12	57
		PR-	10	4	6	40		10	0	100
	HER2		5	2	3	40		4	1	80
	TN		15	1	14	7		3	12	20
ER	+		40	15	25	38	0.014	29	11	73	0.00087
	−		16	1	15	6		4	12	25
PR	+		30	10	20	33	NS (0.32)	19	11	63	NS (0.27)
	−		26	6	20	23		14	12	54
HER2-enrichied	+		5	2	3	40	NS (0.44)	4	1	80	NS (0.19)
	−		51	14	37	27		29	22	57
Menopause	Pre		17	4	13	24	NS (0.80)	9	8	53	NS (0.98)
	Post		45	12	33	27		24	21	53
T stage	Tis		7	1	6	14	0.037	1	6	14	0.018
	T1/2		47	10	37	21		25	22	53
	T3/4		8	5	3	63		7	1	88
Nodal status	+		28	5	23	18	NS (0.10)	15	13	54	NS (0.48)
	−		27	10	17	37		17	10	63
Distant Metastasis	+		3	1	2	33	NS (0.61)	3	0	100	NS (0.14)
	−		53	15	38	28		30	23	57
Grade	DCIS		6	0	6	0	NS (0.15)	0	6	0	0.0055
	1		13	2	11	15		5	8	38
	2/3		43	14	29	33		28	15	65

P was assessed by Pearson's chi-squared test. NS, not significant; Tis, tumor in situ