Table 2. Significant independent prognostic factors for overall survival in patients with pancreatic ductal adenocarcinoma treated by surgical resection on multivariate analysis.
| Characteristics | Category | Hazard Ratio | 95% CI | P value |
|---|---|---|---|---|
| miR-891b expression | Low vs. high | 0.467 | 0.287-0.759 | 0.002 |
| Age (years) | < 60 vs. ≥ 60 | 0.612 | 0.376-0.995 | 0.048 |
| CA19-9 (U/mL) | < 37 vs. ≥ 37 | 4.073 | 1.728-9.601 | 0.001 |
| Differenciation | well | 1 | ||
| moderately | 1.918 | 1.102-3.339 | 0.021 | |
| poorly | 2.951 | 1.481-5.878 | 0.002 |
* The multivariate Cox proportional hazards model (forward) was fitted using all of the clinical and pathological variables, which included age (< 60 vs. ≥ 60 years old), gender (male vs. female), location of tumor (head vs. body or tail), type of operation (pancreaticoduodenectomy vs. distal pancreatectomy vs. total pancreatectomy), maximal tumor diameter, histological differentiation (well vs. moderately vs. poorly differentiated), surgical margins (negative vs. positive), pT category (pT1+pT2 vs. pT3+pT4), pN category (pN0 vs. pN1), vessel invasion (no vs. yes), vascular tumor thrombus (no vs. yes), adjacent organs invasion (no vs. yes), pTNM category (I vs. II vs. III),miR-891b expression (low expression vs. high expression), and CA19-9 level (< 37 U/mL vs. ≥ 37 U/mL).