Table 2. Associations between genetic scores (GSs) of telomere length-related SNPs and nevus count1.
Illumina | Affy | Omni | Meta-analysis2 | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Beta | SE | P-value | Beta | SE | P-value | Beta | SE | P-value | Beta | P-value | P Heterogeneity | |
Simple count GS | 0.003 | 0.008 | 0.67 | 0.009 | 0.007 | 0.21 | −0.001 | 0.008 | 0.90 | 0.004 | 0.33 | 0.66 |
Weighted GS | 0.004 | 0.008 | 0.64 | 0.009 | 0.007 | 0.21 | −0.004 | 0.009 | 0.64 | 0.005 | 0.42 | 0.50 |
Linear regression models were used to assess the relationship between genetic scores (rescaled) and nevus count, adjusting for age, gender, and the top three principle components;
Analyses were first conducted within each of the platform-specific genetic datasets. We used fixed-effect meta-analysis to obtain a combined estimate.