Table 5. Association between GSK3β rs3755557 and APC rs454886 and the acute grade 3–4 radiation-induced toxic reactions.

Radiation-induced toxic reactions	SNP	Genotype distributiona		Model	unadjusted		Adjustedb
		Grade 3–4 (MAF)	Grade 0–2 (MAF)		OR (95% CI)	P	OR (95% CI)	P
Grade 3–4 dermatitis	rs3755557	2/6/8	7/42/123	allelic	2.34 (1.05–5.21)	0.033	—	—
		(0.31)	(0.16)	addictive	2.13 (1.00–4.55)	0.051	—	—
				dominant	2.51 (0.89 –7.06)	0.081	—	—
				recessive	3.37 (0.64–17.77)	0.153	—	—
Grade 3–4 oral mucositis	rs454886	17/43/29	9/49/41	allelic	1.49 ((0.98–2.26)	0.061	—	—
		(0.43)	(0.34)	addictive	1.52 (0.99–2.34)	0.058	1.57 (1.01–2.43)	0.045
				dominant	1.46 (0.81–2.66)	0.212	1.50 (0.82–2.73)	0.191
				recessive	2.36 (0.99–5.61)	0.052	2.54 (1.06–6.13)	0.038

^aIn the order of wild homozygote /heterozygote/ wild type.

^bAdjusted for BMI.

Abbreviations: MAF, minor allele frequency; OR, odds ratio; CI, confidence interval; P value < 0.05 is shown in bold.