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. 2016 Oct 20;7(50):82554–82566. doi: 10.18632/oncotarget.12783

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Copyright: © 2016 Liang et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

PMC Copyright notice

BBD inhibits upstream signal TLR4 expression, and via MyD88 dependent pathway in LPS-induced HSCs. In addition, BBD-serum can down-regulated the expression of α-SMA and inflammatory cytokines throughTLR4/NF-κB pathway. At the same time, BBD can inhibit HSCs proliferation via TLR4/ERK pathway. The element was obtained from Servier Medical Art (http://www.servier.com/servier-medical-art) and the figure was designed and drew by Lei Liang.