Table 3. The efficacy and tolerability of seven treatments according to the network meta-analysis using odds ratios (ORs) and corresponding 95% credible intervals (CrIs).
| Tumor Recurrence | ||||||
|---|---|---|---|---|---|---|
| BCG | 0.63 (0.28, 1.35) | 1.27 (0.67, 2.49) | 0.64 (0.34, 1.18) | 2.51 (1.62, 4.05) | 0.83 (0.43, 1.63) | 1.14 (0.76, 1.73) |
| 1.59 (0.74, 3.57) | BCG_EPI | 2.03 (0.75, 5.91) | 1.02 (0.38, 2.80) | 3.98 (1.66, 10.31) | 1.34 (0.48, 3.78) | 1.81 (0.77, 4.59) |
| 0.79 (0.40, 1.49) | 0.49 (0.17, 1.34) | BCG_INH | 0.50 (0.20, 1.20) | 1.96 (1.04, 3.82) | 0.65 (0.25, 1.61) | 0.90 (0.41, 1.92) |
| 1.56 (0.84, 2.90) | 0.98 (0.36, 2.66) | 1.99 (0.83, 5.04) | BCG_MMC | 3.90 (1.85, 8.74) | 1.30 (0.54, 3.10) | 1.78 (0.96, 3.36) |
| 0.40 (0.25, 0.62) | 0.25 (0.10, 0.60) | 0.51 (0.26, 0.96) | 0.26 (0.11, 0.54) | EPI | 0.33 (0.15, 0.73) | 0.45 (0.25, 0.83) |
| 1.20 (0.61, 2.35) | 0.75 (0.26, 2.08) | 1.54 (0.62, 4.00) | 0.77 (0.32, 1.84) | 3.04 (1.36, 6.86) | GEM | 1.37 (0.66, 2.83) |
| 0.87 (0.58, 1.31) | 0.55 (0.22, 1.30) | 1.12 (0.52, 2.42) | 0.56 (0.30, 1.04) | 2.20 (1.20, 4.04) | 0.73 (0.35, 1.51) | MMC |
| Tumor Progression | ||||||
|---|---|---|---|---|---|---|
| BCG | 0.46 (0.06, 3.07) | 1.73 (0.27, 10.98) | 1.16 (0.22, 5.92) | 2.23 (0.60, 8.60) | 1.35 (0.29, 6.27) | 2.69 (0.80, 8.99) |
| 2.19 (0.33, 17.18) | BCG_EPI | 3.75 (0.26, 58.16) | 2.57 (0.18, 36.01) | 4.89 (0.49, 54.05) | 3.01 (0.24, 36.91) | 5.92 (0.60, 62.73) |
| 0.58 (0.09, 3.70) | 0.27 (0.02, 3.87) | BCG_INH | 0.69 (0.05, 7.84) | 1.31 (0.20, 8.01) | 0.79 (0.07, 8.40) | 1.59 (0.17, 14.16) |
| 0.86 (0.17, 4.63) | 0.39 (0.03, 5.42) | 1.45 (0.13, 18.85) | BCG_MMC | 1.89 (0.25, 16.30) | 1.15 (0.14, 10.37) | 2.31 (0.45, 12.15) |
| 0.45 (0.12, 1.67) | 0.20 (0.02, 2.03) | 0.76 (0.12, 4.91) | 0.53 (0.06, 4.04) | EPI | 0.61 (0.08, 4.36) | 1.19 (0.20, 6.98) |
| 0.74 (0.16, 3.45) | 0.33 (0.03, 4.19) | 1.26 (0.12, 14.80) | 0.87 (0.10, 7.31) | 1.64 (0.23, 12.63) | GEM | 1.99 (0.32, 11.86) |
| 0.37 (0.11, 1.25) | 0.17 (0.02, 1.65) | 0.63 (0.07, 5.75) | 0.43 (0.08, 2.23) | 0.84 (0.14, 5.06) | 0.50 (0.08, 3.09) | MMC |
| Disease-specific Mortality | |||||
|---|---|---|---|---|---|
| BCG | 0.94 (0.02, 62.49) | 1.02 (0.34, 3.21) | 0.66 (0.24, 1.50) | 1.45 (0.61, 3.36) | 1.04 (0.44, 2.39) |
| 1.06 (0.02, 50.15) | BCG_EPI | 1.08 (0.01, 58.75) | 0.67 (0.01, 33.01) | 1.51 (0.02, 77.52) | 1.06 (0.01, 53.12) |
| 0.98 (0.31, 2.95) | 0.93 (0.02, 71.92) | BCG_INH | 0.65 (0.13, 2.41) | 1.41 (0.45, 4.02) | 1.02 (0.22, 4.01) |
| 1.52 (0.67, 4.24) | 1.49 (0.03, 108.70) | 1.54 (0.41, 7.68) | BCG_MMC | 2.19 (0.68, 8.20) | 1.56 (0.58, 5.14) |
| 0.69 (0.30, 1.63) | 0.66 (0.01, 46.96) | 0.71 (0.25, 2.20) | 0.46 (0.12, 1.48) | EPI | 0.72 (0.22, 2.37) |
| 0.96 (0.42, 2.30) | 0.94 (0.02, 66.73) | 0.98 (0.25, 4.45) | 0.64 (0.19, 1.73) | 1.40 (0.42, 4.63) | MMC |
| Fever | |||||
|---|---|---|---|---|---|
| BCG | 0.40 (0.04, 2.88) | 1.87 (0.23, 10.82) | 0.61 (0.08, 2.16) | 0.33 (0.03, 2.78) | 0.16 (0.04, 0.50) |
| 2.48 (0.35, 23.42) | BCG_EPI | 4.39 (0.26, 71.94) | 1.40 (0.08, 18.35) | 0.78 (0.04, 17.48) | 0.40 (0.03, 4.84) |
| 0.54 (0.09, 4.42) | 0.23 (0.01, 3.89) | BCG_INH | 0.32 (0.04, 1.89) | 0.18 (0.01, 3.79) | 0.09 (0.01, 0.97) |
| 1.64 (0.46, 12.65) | 0.71 (0.05, 12.55) | 3.10 (0.53, 26.47) | EPI | 0.57 (0.04, 11.29) | 0.26 (0.04, 2.67) |
| 3.02 (0.36, 37.16) | 1.29 (0.06, 28.39) | 5.68 (0.26, 109.10) | 1.76 (0.09, 26.83) | GEM | 0.48 (0.04, 7.08) |
| 6.31 (2.01, 25.05) | 2.50 (0.21, 29.69) | 11.60 (1.03, 123.98) | 3.78 (0.37, 23.27) | 2.06 (0.14, 27.16) | MMC |
| Cystitis | |||||
|---|---|---|---|---|---|
| BCG | 0.68 (0.16, 2.59) | 0.13 (0.01, 2.32) | 0.34 (0.08, 1.31) | 0.22 (0.02, 2.31) | 0.79 (0.08, 6.14) |
| 1.47 (0.39, 6.09) | MMC | 0.19 (0.01, 2.49) | 0.49 (0.07, 3.74) | 0.32 (0.02, 5.47) | 1.13 (0.08, 13.65) |
| 7.72 (0.43, 159.74) | 5.23 (0.40, 79.26) | GEM | 2.59 (0.10, 71.24) | 1.69 (0.04, 79.64) | 5.95 (0.15, 231.17) |
| 2.97 (0.76, 12.83) | 2.03 (0.27, 15.33) | 0.39 (0.01, 9.53) | EPI | 0.65 (0.04, 11.41) | 2.31 (0.27, 19.31) |
| 4.56 (0.43, 47.81) | 3.13 (0.18, 48.99) | 0.59 (0.01, 23.00) | 1.54 (0.09, 23.08) | BCG+EPI | 3.49 (0.13, 80.12) |
| 1.27 (0.16, 12.04) | 0.88 (0.07, 12.54) | 0.17 (0.00, 6.87) | 0.43 (0.05, 3.76) | 0.29 (0.01, 7.99) | BCG + INH |
| Haematuria | |||||
|---|---|---|---|---|---|
| BCG | 0.31 (0.04, 2.28) | 0.21 (0.01, 4.65) | 0.19 (0.02, 1.17) | 0.27 (0.01, 5.02) | 0.55 (0.02, 16.14) |
| 3.22 (0.44, 26.17) | MMC | 0.68 (0.03, 15.37) | 0.60 (0.03, 9.25) | 0.85 (0.02, 32.72) | 1.80 (0.03, 94.56) |
| 4.75 (0.21, 104.85) | 1.46 (0.07, 33.05) | GEM | 0.87 (0.02, 27.84) | 1.23 (0.02, 99.40) | 2.61 (0.03, 233.17) |
| 5.37 (0.86, 41.23) | 1.66 (0.11, 29.78) | 1.15 (0.04, 46.72) | EPI | 1.43 (0.05, 53.28) | 3.00 (0.10, 96.15) |
| 3.76 (0.20, 80.76) | 1.18 (0.03, 45.96) | 0.81 (0.01, 64.93) | 0.70 (0.02, 20.87) | BCG + EPI | 2.09 (0.02, 194.73) |
| 1.82 (0.06, 57.61) | 0.56 (0.01, 28.65) | 0.38 (0.00, 35.66) | 0.33 (0.01, 9.75) | 0.48 (0.01, 45.77) | BCG + INH |
*BCG: Bacille Calmette Guerin; MMC: Mytomicin C; GEM: Gemcitabine; EPI: Epirubicin; INH: Isoniazid.