Figure 3. Silencing PVT1 by siRNA inhibits migration and invasion and induces cell cycle arrest in osteosarcoma cells.
(A–C) A Transwell assay was performed to assess the migration of U2OS and MG-63 cells transfected with control or si-PVT1#1; Magnification 200×, Scale bars = 10 μm, (*P < 0.05). (D–F) A Transwell assay was performed to assess the invasiveness of U2OS and MG-63 cells transfected with control or si-PVT1#1; Magnification 200×, Scale bars = 10 μm, (*P < 0.05). (G) The cell cycle distribution was assessed by flow cytometry in U2OS cells transfected with control or si-PVT1#1. (H) The cell cycle distribution was detected by flow cytometry in MG-63 cells transfected with control or si-PVT1#1.