Figure 1. Expression of hCtr1 and ASS1 in cDDP-sensitive and cDDP-resistant cell lines and their differential sensitivities to ADI-PEG20.
A. Immunoblots showing the expression of hCtr1 and ASS1 in six pairs of cDDP-sensitive (left side) vs cDDP-resistant (right) cell lines. B. Concentration-dependent sensitivity to ADI-PEG20 of four randomly chosen pairs of cDDP-resistant vs cDDP-sensitive cell lines to ADI-PEG20 for 24 hr as determined by the SRB assay.