Table 3. Univariate and multivariate Cox proportional hazard regression analyses of the association of clinicopathological characteristics and the four genes' expression levels with DFS.
| Characteristics | Univariate | Multivariate | Multivariate | |||
|---|---|---|---|---|---|---|
| HR(95%CI) | P | HR(95%CI) | P | HR(95%CI) | P | |
| Gender(Female vs Male) | 0.961(0.600-1.541) | 0.870 | - | - | - | - |
| Age (≤55 years vs >55 years) | 0.937(0.577-1.522) | 0.792 | - | - | - | - |
| Grade (1, 2 vs 3, 4) | 2.195(1.354-3.558) | 0.001* | 1.471(0.844-2.562) | 0.173 | 1.522(0.888-2.609) | 0.127 |
| Size (≤7cm vs >7cm) | 2.147(1.326-3.477) | 0.002* | 1.527(0.864-2.697) | 0.145 | 1.353(0.777-2.357) | 0.285 |
| Stage (I, II vs III, IV) | 2.395(1.367-4.197) | 0.002* | 1.631(0.847-3.142) | 0.143 | 1.484(0.780-2.825) | 0.229 |
| PTEN (Negative vs Postive) | 0.515(0.318-0.835) | 0.007* | 0.420(0.249-0.708) | 0.001* | - | - |
| BCL3 (Negative vs Postive) | 2.193(1.328-3.620) | 0.002* | 1.671(0.984-2.838) | 0.057 | - | - |
| ITPA (Negative vs Postive) | 1.686(1.050-2.709) | 0.031* | 2.161(1.295-3.604) | 0.003* | - | - |
| PIK3C2A (Negative vs Postive) | 0.471(0.294-0.754) | 0.002* | 0.512(0.317-0.828) | 0.006* | - | - |
| Risk (Low Risk vs High Risk) | 3.111(1.916-5.050) | <0.001* | - | - | 2.693(1.637-4.432) | <0.001* |
Grade: Furhman Grade; HR, hazard ratio; CI, Confidence Interval; P Values were obtained from the Chi-square test. * P <0.05 was considered to be statistically significant.