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. 2016 Oct 13;7(50):82757–82769. doi: 10.18632/oncotarget.12634

Figure 1. SAR405838 shows cytotoxic effects on p53 wild-type NB cell lines.

Figure 1

A. Four NB cell lines were treated with increasing concentrations of SAR405838 for 72 hours or increasing treatment hours at 10 μM. Cell viability was assessed by CCK-8 assay. Data is represented as % vehicle ± S.D. with P < 0.05 (*), P < 0.01 (**), or P < 0.001 (***) (Student's t-test, two-tailed) as indicated. B. The IC50 values of SAR405838 in each cell line listed were calculated in Prism 5 and based on the data collected in the cell viability assay. p53 status in NB cell lines was also shown. C. Morphological changes of the four different NB cell lines treated with increasing concentrations of SAR405838 for 72 hours were shown.