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. 2016 Oct 13;7(50):82757–82769. doi: 10.18632/oncotarget.12634

Figure 3. SAR405838 activates p53 downstream signaling pathway, and induces apoptosis in p53 WT NB cells.

Figure 3

IMR-32, SH-SY5Y and SK-N-AS cells treated with 20 μM of SAR405838 and LA-N-6 cells with 50 μM of SAR405838 for various time points (0-12 hours), were lysed and subjected to SDS-PAGE followed by immunoblotting with the antibodies indicated. The anti-α Tubulin antibodies were used as a loading control for whole cell extracts.