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. 2016 Oct 13;7(50):82757–82769. doi: 10.18632/oncotarget.12634

Figure 4. SAR405838 enhances the cytotoxic effect of Doxorubicin on NB cell lines.

Figure 4

A. IMR-32, SH-SY5Y, and LA-N-6 cells were seeded in 96-well plates and incubated with the indicated concentrations of Dox plus DMSO or 5 μM of SAR405838 for 24 hours. Cell viability was then measured by CCK-8 assay. B. IMR-32, SH-SY5Y, and LA-N-6 cells were treated with either Dox (2 μM) alone, SAR405838 (5 μM) alone, or a combination of both for 8 hours. Then cells were lysed and subjected to SDS-PAGE followed by immunoblotting with the antibodies indicated. The α Tubulin antibodies were used as a loading control for whole cell extracts.