Table 1. Genotype and allele frequencies of the P2RX7 253 T/C polymorphism in controls and in women with CSCC and those with HPV-16 positive CSCC*.
| Controls (N =1619) |
CSCC (N = 507) |
HPV-16 positive CSCC (N = 240) |
CSCC | HPV-16 positive CSCC | |||
|---|---|---|---|---|---|---|---|
| n (%) | n (%) | n (%) | P value (χ) | OR (95% CI) | P value (χ) | OR (95% CI) | |
| Genotype | 0.01 (8.74) | 0.002 (12.1) | |||||
| T/T | 1507 (93.1) | 479 (94.5) | 227 (94.6) | 1.27 (0.83-1.95) | 1.30 (0.72-2.34) | ||
| T/C | 110 (6.8) | 24 (4.7) | 10 (4.2) | 0.68 (0.43-1.07) | 0.60 (0.31-1.16) | ||
| C/C | 2 (0.1) | 4 (0.8) | 3 (1.3) | 6.43 (1.02-50.6) | 10.2 (1.39-87.8) | ||
| Allele | 0.58 (0.31) | 0.83 (0.04) | |||||
| T | 3124 (96.5) | 982 (96.8) | 464 (96.7) | 1.12 (0.75-1.67) | 1.06 (0.62-1.80) | ||
| C | 114 (3.5) | 32 (3.2) | 16 (3.3) | 0.89 (0.60-1.33) | 0.94 (0.55-1.61) | ||
*CSCC = cervical squamous cell carcinoma; HPV = human papillomavirus; OR = odds ratio; CI = confidence interval.