Table 2. Summary of NGS ALK fusion detection and FISH patterns.
FISH PATTERN | NEXT GENERATION SEQUENCING | |||
---|---|---|---|---|
POSITIVE FOR EML4-ALK FUSION | POSITIVE FOR ALK FUSION BY 3′/5' READ RATIO ONLY | NEGATIVE | TOTAL POSITIVE | |
Split signal (N=15) | 10 (67%) |
2 (13%) |
3 (20%) |
12 (80%) |
Single orange (N=10) |
2 (20%) |
2 (20%) |
6 (60%) |
4 (40%) |
Mixed pattern (N=3) | 0 (0%) |
0 (0%) |
3 (100%) |
0 (0%) |